Cancers, Free Full-Text
By A Mystery Man Writer
Description
Until recently, despite its heterogenous biology, metastatic triple negative breast cancer (TNBC) was treated as a single entity, with successive lines of palliative chemotherapy being the only systemic option. Significant gene expression studies have demonstrated the diversity of TNBC, but effective differential targeting of the four main (Basal-like 1 and 2, mesenchymal and luminal androgen receptor) molecular sub-types has largely eluded researchers. The introduction of immunotherapy, currently useful only for patients with PD-L1 positive cancers, led to the stratification of first-line therapy using this immunohistochemical biomarker. Germline BRCA gene mutations can also be targeted with PARP inhibitors in both the adjuvant and metastatic settings. In contrast, the benefit of the anti-Trop-2 antibody-drug conjugate (ADC) Sacituzumab govitecan (SG) does not appear confined to patients with tumours expressing high levels of Trop-2, leading to its potential utility for any patient with an estrogen receptor (ER)-negative, HER2-negative advanced breast cancer (ABC). Most recently, low levels of HER2 expression, detected in up to 60% of TNBC, predicts benefit from the potent HER2-directed antibody-drug conjugate trastuzumab deruxtecan (T-DXd), defining an additional treatment option for this sub-group. Regrettably, despite recent advances, the median survival of TNBC continues to lag far behind the approximately 5 years now expected for patients with ER-positive or HER2-positive breast cancers. We review the data supporting immunotherapy, ADCs, and targeted agents in subgroups of patients with TNBC, and current clinical trials that may pave the way to further advances in this challenging disease.
Cancer Images - Free Download on Freepik
Cancers, Free Full-Text
Cancers, Free Full-Text, papa's burgeria poki
I AM Cancer Free, Get Well Soon Craft Activity, Get Well Wishes
Cancers, Free Full-Text, kitka games 44
Incipient Cancer Photos and Images & Pictures, Pink And Red Ribbon
Cancers, Free Full-Text, kitka games 44
Current Oncology, Free Full-Text, Skin Tone Construction Paper
Cancers, Free Full-Text, kitka games 44
Cancers, Free Full-Text
The Imaginary Journal of Poetic Economics: Cancer Literature: 13% Free
Royalty Free Footages
Cancers, Free Full-Text
Cancers, Free Full-Text, scp 666 1/2 j
Pharmaceuticals Free Full-Text Preclinical Efficacy And, 54% OFF
from
per adult (price varies by group size)